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KMID : 0369319940140020229
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Allergy
1994 Volume.14 No. 2 p.229 ~ p.237
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Comparison of Therapeutic Effect of Metered Dose Inhaler with Spacer to Nebulizer in Acute Childhood Asthma
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Abstract
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Nebulizer has been widely used to treat acute asthma in children including infants, but recently metered dose inhaler attached with spacer(MDIS) was reported to results in significantly greater bronchodilator than nebulizer, and has several
advantages:
it is cheaper, more convenient, easy to clean, independent of eletricity and reduces the problem of coordination. This study was done to compare the therapeutic effect of metered dose inhaler with spacer(MDIS) with those of the nebulizer in 40
acute
asthmatic children who were admitted to department of Pediatrics of EWHA, from Jan. 1990 to July 1991.
The subjects were randomly allocated into MDIS and nebulized salbutamol groups.
@ES The results were as follows:
@EN 1) In MDIS group, wheeze score was 0.8±0.5 which was significantly lower than 1.6±0.9 in nebulized group (P<0.01). Respiratory rate in MDIS group was 30.7±5.8 which was significantly lower than 35.1±5.7 in nebulized group (P<0.05).
Heart rate and retraction score were not significantly difference between two groups.
2) Duration of wheezing in MDIS group 4.7±2.1 days which was not significantly different to 4.9±2.2days in nebulized group. Initial and maintenance dose for salbutamol in MDIS group were 790±238㎍/dose, 800㎍/day which were much smaller than
2.5mg/dose, 10mg/day in nebulizer group.
3) The side effects in MDIS group were not significantly different to nebulized group. Significant paradoxical bronchoconstriction in nebulized group was not documented in the study.
In conclusion, method dose inhaler with spacer is cheaper, more convenient, and more effective than nebulizer. So we think that MDIS could be recommended in acute childhood asthma.
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KEYWORD
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